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Anti-GBM antibodies - possible false positives

We have received a field safety notice from our anti-GBM antibody assay manufacturer (Phadia), stating that their assay design 'may contribute to the identification of some false positive GBM results for specific samples containing anti-BSA antibodies'. This affects both weak and strong positive anti-GBM antibody results.

As a result we are now routinely sending all first time positive anti-GBM antibodies (results >10 U/mL) to Tayside Immunology laboratory for confirmation by immunoblot assay. Tayside have confirmed that they perform this immunoblot assay weekly.

We will continue to phone all first time positive anti-GBM antibody results to the requesting clinician/ward/external laboratory.

Further details are available within the attached letter available for download below. Please contact us if you have any further questions.

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